目的 :通过观察肾组织电镜下结构改变探讨缺血预处理 (IPC)在肾缺血再灌流 (IR)损伤中的作用 ,以及IPC2、3、4次对IR肾作用是否具有差异性。方法 :在 6 3只日本大耳白兔 ,采用肾动脉夹闭造成IR肾损伤动物模型 ,IPC +IR组在缺血前分别预处理 2、3、4次 ,单纯缺血再灌流组仅手法模拟。结果 :IR组肾组织发生明显变性、坏死改变 ,而IPC +IR组病变轻微。结论 :IPC可减轻IR所造成的肾组织损伤 ,IPC2、3、4次间作用无明显差异。 OBJECTIVE: To investigate the role of ischemic preconditioning (IPC) in renal ischemia-reperfusion (IR) injury by observing the structural changes of renal tissue under electron microscopy and whether there is a difference in the effects of IPC 2, Methods: Sixty three Japanese white rabbits were inflicted with IR renal injury by clipping the renal artery. The rats in IPC + IR group were pretreated twice, three, four times before ischemia, while those in ischemia / reperfusion group simulation. Results: The renal tissue of IR group had obvious degeneration and necrosis, while the lesions in IPC + IR group were mild. Conclusion: IPC can reduce renal damage caused by IR, IPC 2, 3, 4 times no significant difference between the role.