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目的 探讨激光焊接神经的基本机制。rn方法 SD大白鼠24只，随机分为激光焊接组和传统外膜缝合组，每组12只。游 离大鼠坐骨神经，从中段剪断行神经断端对合后，激光组用氩激光(波长514.5 nm，石英 光纤芯径600 μm，功率700 mW，光斑直径1 mm)，照射对合处一圈；缝合组用11-0号尼龙 缝线缝合对合处的神经外膜。于术后10天、1个月和3个月对再生神经用光镜、电镜进行组织 形态学观察，术后3个月用电生理仪进行功能测试，比较两组间的差异。rn结果 组织形态学观察：术后10天，激光组的神经膜细胞明显多于缝合组；术 后1个月再生神经纤维生长，数量比缝合组多；术后3个月，激光组的再生神经纤维密度大， 且分布均匀，吻合部位的神经纤维连续性良好且平直，明显好于缝合组，神经电生理测试： 术后3个月测定再生神经的传导速度(CV)和复合动作电位峰值(AP)，激光组优于缝合组。rn结论 在激光焊接神经外膜的同时，透过神经外膜进入神经组织内的漫射激光 刺激了神经膜细胞，加速其不断分裂增殖，而增殖的神经膜细胞又增强了损伤神经的再生。“,”Objective To explore the basic mechanism of nerve laser welding. rnMethods A comparative study between sciatic nerve epine urial welding with Ar+ laser and conventional suture techniques was made on 24 rats. After operation on the nerves, optical and electron microscopic examinati on and electrophysiological tests were carried out.rnResults The histopathological examination revealed that at 10 days a fter operation, obviously more Schwann-cells were present in laser group than i n suture group. 1 months after operation, the number of regenerated nerve fiber s in laser group is more abundant than in suture group. 3 months after operation , the nerve regeneration in laser group is better than that in suture group. Ele ctrophysiological test showed that at 3 months after operation, the CV and AP in laser group excel those in suture group.rnConclusions At the same time as the epineurium was welded by laser, the diffuse light of laser penetrated the epineurium into the neural tissue an d stimulated Schwann cell which was sped up to divide and proliferate continuous ly. Therefore, these Schwann-cells may further strengthen the regeneration of damaged nerves.