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目的探讨前列腺特异抗原移行区密度(PSAT)在前列腺癌早期诊断中的作用。方法在血清PSA>4.0 ng/ml,并接受前列腺活检的144例受检者为研究对象,根椐病理学诊断分为前列腺癌组(PCa组)、良性前列腺增生组(BPH组);血清PSA含量应用瑞典CanAG公司试剂盒;经直肠超声测量前列腺癌体积和移行区体积,分别计算前列腺特异抗原密度(PASD)和PSAT。应用SPSS(10.0)软件进行统计学分析。结果(1)受检者的前列腺移行区体积与前列腺总体积呈明显正相关(r=0.78,P<0.001)。(2)BPH组与PCa组比校,总体积无显著差别(P>0.05),前列腺移行区体积、PSA、PSADP、SAT均有显著差别。ROC曲线显示PSAT的曲线下面积(AUC)为0.771大于PSA、PSAD,且有显著差别(P<0.01)。(3)在灰色区域,PSAT在BPH组和PCa组中存在显著差别;ROC曲线表明PSAT强于PSAD。结论前列腺特异抗原移行区密度是提高前列腺癌早期诊断效率的有效指标。
Objective To investigate the role of PSAT in the early diagnosis of prostate cancer. Methods 144 cases of subjects with serum PSA> 4.0 ng / ml and undergoing prostate biopsy were divided into three groups: prostate cancer group (PCa group), benign prostatic hyperplasia group (BPH group), serum PSA The content of the kit was measured by CanAG kit of Sweden. Prostate cancer volume and transitional zone volume were measured by transrectal ultrasound, and prostate specific antigen density (PASD) and PSAT were calculated respectively. SPSS (10.0) software was used for statistical analysis. Results (1) There was a significant positive correlation between the volume of prostate transitional region and the total prostate volume (r = 0.78, P <0.001). (2) There was no significant difference in the total volume between the BPH group and the PCa group (P> 0.05). There was a significant difference in the volume, PSA, PSADP and SAT in the BPH group. The ROC curve showed that the area under curve (AUC) of PSAT was 0.771 greater than that of PSA and PSAD, and there was a significant difference (P <0.01). (3) In the gray area, PSAT has significant difference in BPH group and PCa group; ROC curve shows that PSAT is stronger than PSAD. Conclusion The density of transitional region of prostate specific antigen is an effective index to improve the early diagnosis of prostate cancer.