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目的:观察右美托咪定(DEX)联合七氟烷用于结直肠癌手术的麻醉效果。方法:选择结直肠癌手术60例,随机分为观察组和对照组各30例。两组术中均采用七氟烷吸入麻醉;观察组术中给予DEX泵注,对照组给予等量生理盐水泵注。比较两组手术开始(t_0)、开始后15min(t_1)、30min(t_2)、60min(t_3)时吸入七氟烷的最低肺泡有效浓度(MAC)值、双频指数(BIS)、平均血压(MAP)、心率(HR)、术后睁眼时间、拔管时间及术后躁动评分等。结果:观察组t_0-t_3时的HR和MAC值显著低于对照组同时间节点(P<0.05);MAP和BIS值两组比较,差异不显著(P>0.05)。观察组睁眼时间、拔管时间和躁动评分分值均显著早(低)于对照组(P<0.05)。结论:DEX联合七氟烷用于结直肠癌手术麻醉效果优于单用七氟烷。
Objective: To observe the anesthetic effects of dexmedetomidine (DEX) combined with sevoflurane in colorectal cancer surgery. Methods: Sixty cases of colorectal cancer were selected and randomly divided into observation group and control group with 30 cases each. Sevoflurane inhalation anesthesia was used in both groups. DEX pump was used in the observation group and saline injection in the control group. The minimum effective concentration of sevoflurane (MAC), dual-frequency index (BIS), mean blood pressure (BIS), blood pressure and blood pressure were compared between the two groups at the beginning of operation (t_0), 15min (t_1), 30min (t_2) and 60min (t_3) MAP), heart rate (HR), open eyes time, extubation time and postoperative agitation score. Results: The HR and MAC values of t_0-t_3 in observation group were significantly lower than those in control group at the same time point (P <0.05). There was no significant difference in MAP and BIS between the two groups (P> 0.05). Eyes open time, extubation time and agitation score in observation group were significantly earlier (lower) than those in control group (P <0.05). CONCLUSIONS: DEX combined with sevoflurane is superior to sevoflurane in surgical anesthesia for colorectal cancer.