国外学者应用六氯对二甲苯治疗肝片吸虫病和猫后睾吸虫病有效。近年来我们应用此药治疗中华分枝睾吸虫病、肺吸虫病等获得较好的疗效。此药在体內具有明显的积累作用,长期使用后常导致患者出现无力、疲倦、食欲不振、头晕、头疼等毒性反应;此种反应与氯喹和依米丁所引起者有相似之处。我们以前曾经报导氯喹和依米丁所引起的毒性反应可能是与此二药物抑制大白鼠肝线粒体的氧化磷酸化作用,从而使其高能化合物的合成障碍有关。我们推想HPX可能也有解偶联氧化磷酸化的作用,因此我们观察了口服HPX油剂对大白鼠肝线粒体氧化磷酸化作用的影 Foreign scholars using hexachlorophenylene paracetamolis and fistula treatment is effective. In recent years, we use this medicine for the treatment of Clonorchis sinensis, paragonimiasis get better results. This drug has a significant accumulation in the body, after long-term use often leads to patients with weakness, fatigue, loss of appetite, dizziness, headache and other toxic reactions; this reaction with chloroquine and emetine caused by those who have similarities. We have previously reported that the toxic effects of chloroquine and emetine may be related to their inhibitory effect on the oxidative phosphorylation of rat liver mitochondria, thus making their synthesis of high energy compounds difficult. We hypothesized that HPX may also have the effect of uncoupling oxidative phosphorylation, so we looked at the effect of oral HPX oil on the oxidative phosphorylation of rat liver mitochondria