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目的:报道激素联合环磷酰胺治疗视神经脊髓炎谱系疾病患者1例,并对相关文献进行复习。方法:对1例诊断为视神经脊髓炎谱系疾病患者进行相关实验室检查(包括水通道蛋白4)和辅助检查,并基于临床实践,给予激素联合环磷酰胺治疗。结果:该患者以渐进性右眼视物模糊伴右侧肢体无力、麻木起病,诊断为视神经脊髓炎谱系疾病。治疗方面,先给予激素冲击治疗,但患者病情不断进展且对激素产生依赖性,遂加用环磷酰胺,使患者的病情得到了有效控制。结论:对于视神经脊髓炎谱系疾病激素治疗不佳的患者,激素联合环磷酰胺治疗可以明显改善其临床症状。
OBJECTIVE: To report a case of hormone combined with cyclophosphamide in the treatment of optic neuromyelitis disease, and to review the relevant literature. METHODS: One laboratory diagnosed with optic neuromyelitis was diagnosed with laboratory tests (including aquaporin 4) and laboratory tests. Hormone plus cyclophosphamide was given based on clinical practice. Results: The patient with progressive right eye blurred vision with the right limb weakness, numbness onset, diagnosed as optic neuromyelitis spectrum disease. Treatment, the first hormone therapy, but the patient’s condition continues to progress and hormone-dependent, then add cyclophosphamide, the patient’s condition has been effectively controlled. CONCLUSIONS: Hormones combined with cyclophosphamide can significantly improve clinical symptoms in patients with poorly managed hormones of the optic neuromyelitis spectrum.