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采用３Ｈ－Ｄｅｘ放射配体结合分析法测定２２例正常人及２０例哮喘患者在糖皮质激素（ＧＣ）治疗前后外周血白细胞中糖皮质激素受体（ＧＣＲ）水平。结果：哮喘患者外周血白细胞ＧＣＲ（３９６６±１１０９位点／细胞）明显低于健康正常人（５２５４±１２８９位点／细胞）（Ｐ＜０．０５）；哮喘患者经ＧＣ治疗一周后，其白细胞中ＧＣＲ（２０９１±４９４）明显低于治疗前（Ｐ＜０．０５）；但哮喘患者ＧＣ敏感组白细胞中ＧＣＲ与ＧＣ耐受组之间无显著差异（Ｐ＞０．０５），并对其发生机制作了初步探讨
The levels of glucocorticoid receptor (GCR) in peripheral blood leukocytes of 22 normal subjects and 20 asthmatic patients before and after glucocorticoid (GC) treatment were determined by 3H-Dex radioligand binding assay. Results: The GCR (3966 ± 1109 loci / cell) of asthmatic patients was significantly lower than that of healthy controls (5254 ± 1289 loci / cell) (P <0.05) GCR (2091 ± 494) was significantly lower than that before treatment (P <0.05). However, there was no significant difference (P> 0.05) between GCR and GC tolerance group in GC sensitive group Occurrence mechanism made a preliminary discussion