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对合成的壳聚糖-聚丙烯酸及磁性壳聚糖-聚丙烯酸微球用扫描电镜进行形貌观察,并测定了磁性壳聚糖-聚丙烯酸微球的热稳定性。以牛血清白蛋白(BSA)为模拟蛋白药物,研究了载有BSA的磁性壳聚糖-聚丙烯酸微球的释放性能。结果表明,壳聚糖-聚丙烯酸共聚物外形呈片层状;而磁性壳聚糖-聚丙烯酸微球为致密微球,粒径约在100~400 nm之间,具有较好的分散性,磁性壳聚糖-聚丙烯酸微球在温度区间(0~135℃)内具有良好的热稳定性。载有BSA的磁性微球在模拟肠液中刚开始时有一个突释过程,之后缓慢释放,在6h左右达到了平衡,最终释放率可达到80.5%;而在模拟胃液中几乎没有释放,平衡释放率只有5.8%。
The morphology of the synthesized chitosan-polyacrylic acid and magnetic chitosan-polyacrylic acid microspheres was observed by scanning electron microscopy and the thermal stability of the magnetic chitosan-polyacrylic acid microspheres was determined. Using bovine serum albumin (BSA) as a mimic protein drug, the release properties of magnetic chitosan-polyacrylic acid microspheres loaded with BSA were studied. The results showed that the shape of chitosan-polyacrylic acid copolymer was lamellar, while magnetic chitosan-polyacrylic acid microspheres were dense microspheres with particle size of about 100-400 nm with good dispersibility, Magnetic chitosan - polyacrylic acid microspheres in the temperature range (0 ~ 135 ℃) has good thermal stability. Magnetic microspheres containing BSA had a burst process at the beginning of the simulated intestinal fluid, then released slowly and reached equilibrium at about 6h, with a final release rate of 80.5%. However, there was almost no release in the simulated gastric fluid and the equilibrium release The rate is only 5.8%.