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目的分析杭州市西湖区学龄前儿童病毒性乙型肝炎血清标志物的分布和流行规律。方法选取杭州市西湖区2010-2012年间0~6岁的学龄前儿童2 578例,利用ELISA法检测儿童体血清内HBsAg、anti-HBs、HBeAg、anti-HBe、anti-HBc水平。结果 HBsAg及anti-HBs的阳性检出率分别为1.12%和57.76%,男性学龄前儿童的HBsAg的阳性检出率要显著高于女性学龄前儿童,而女性学龄前儿童的anti-HBs的阳性检出率要显著高于男性儿童。2010、2011、2012连续三年的动态监测发现anti-HBs的阳性检出率呈现出逐年上升的趋势,而HBsAg的阳性检出率则呈现出逐年降低的趋势。结论定期的对学龄前儿童进行乙型肝炎血清标志物的检测,并及时的对其中的易感人群进行疫苗的补种,这样才能有效的防止乙肝的感染。
Objective To analyze the distribution and prevalence of serum hepatitis B virus markers in preschool children in West Lake District of Hangzhou. Methods A total of 2 578 preschool children aged 0-6 years from 2010 to 2012 in Hangzhou were enrolled. The serum levels of HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc in children were detected by ELISA. Results The positive rates of HBsAg and anti-HBs were 1.12% and 57.76%, respectively. The positive rate of HBsAg in preschool children was significantly higher than that of female preschool children, while the positive rate of anti-HBs in female preschool children The detection rate should be significantly higher than male children. During the three years of continuous monitoring in 2010, 2011 and 2012, the positive detection rate of anti-HBs showed an increasing trend year by year, while the positive detection rate of HBsAg showed a decreasing trend year by year. Conclusion Regular detection of hepatitis B serum markers in pre-school children and prompt re-vaccination of the susceptible population in order to effectively prevent hepatitis B infection.