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目的探讨脑梗死超急性期弥散张量成像(DTI)对兔脑梗死后出血(HT)的预测作用。方法35只兔经颈内动脉插管注入自体血栓建立急性血栓性脑梗死模型。术后3 h常规MR检查,证实为脑梗死后行兔脑冠状面DTI,72 h后处死动物、取脑,观察大体标本及显微镜下梗死区有无出血及其程度,比较HT组与无HT组、有HT动物的HT区与非HT区、HI与PH区DTI参数变化差异。结果26只动物(74.29%)模型制作成功,无HT者8只(30.77%,8/28)、HT者18只(69.23%,18/26),HT组包括HI组14只(53.85%)及PH组4只(15.38%)。HT组与非HT组T2加权示踪(T2WT)、平均扩散系数(DC_(avg))、各向异性系数(FA)、容积比(1-VR)、指数衰减(EA)均有明显差异(P<0.001～P= 0.039)。有HT动物的HT区与非HT区的T2WT、DC_(avg)、FA、及EA值差异显著(P<0.001),1-VR值无明显差别。HI组与PH组HT区DTI各参数无显著差异(P>0.05)。结论DTI有可能预测兔脑梗死后是否继发出血。
Objective To investigate the predictive value of hyperacute diffusion tensor imaging (DTI) in cerebral infarction on hemorrhage (HT) after cerebral infarction in rabbits. Methods Thirty - five rabbits were injected with autologous thrombus through the internal carotid artery to establish acute thrombotic cerebral infarction model. After 3 h of routine MR examination, the coronal DTI of the rabbit’s brain was confirmed after cerebral infarction, and the animals were sacrificed at 72 h after brains were taken for observation of gross and microscopic infarct bleeding and extent of bleeding. Group HT animals with HT animals and non-HT, HI and PH DTI parameters of the difference. RESULTS: Twenty-six animals (74.29%) were successful in the model. There were 8 (30.77%, 8/28) patients without HT, 18 (69.23%, 18/26) with HT, and 14 (53.85% And PH group 4 (15.38%). T2 weighted tracing (T2WT), average diffusion coefficient (DC_ (avg)), anisotropy index (FA), volume ratio (1-VR) and exponential decay (EA) were significantly different between HT group and non-HT group P <0.001 ~ P = 0.039). There were significant differences in T2WT, DC_ (avg), FA, and EA values between HT and non-HT regions in HT animals (P <0.001). There was no significant difference in 1-VR values. There was no significant difference in DTI parameters between HI group and PH group (P> 0.05). Conclusion DTI may predict whether secondary hemorrhage occurs after cerebral infarction in rabbits.