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目的:对子宫肌瘤患者实施聚焦超声消融治疗,观察其疗效及对子宫肌瘤中孕激素受体(PR)和雌激素受体(ER)的表达水平的影响。方法:选取我院自愿接受聚焦超声消融手术进行治疗的108例子宫肌瘤患者,对患者术前及术后6个月的PR和ER的表达水平进行测定,观察临床症状的改善情况和子宫肌瘤体积的变化,统计学分析比较术前和术后6个月的差异。结果:术后患者PR和ER在子宫肌瘤层的表达水平有明显的降低,显著低于治疗前的表达水平。结论:聚焦超声消融可以有效的改善患者临床症状,缩小子宫肌瘤体积,降低子宫肌瘤层中PR和ER的表达水平。该方法安全有效,值得在临床中探讨和研究。
Objective: To perform focused ultrasound ablation therapy on uterine leiomyoma and observe its curative effect and its effect on the expression of progesterone receptor (PR) and estrogen receptor (ER) in uterine leiomyoma. Methods: 108 patients with uterine leiomyoma who were treated by FOCUS in our hospital were enrolled in this study. The expression of PR and ER were measured before and 6 months after operation. The improvement of clinical symptoms and uterine muscle Tumor volume changes, statistical analysis of preoperative and postoperative 6 months difference. Results: The expression of PR and ER in uterine fibroids was significantly decreased after operation, which was significantly lower than that before treatment. Conclusion: Focused ultrasound ablation can effectively improve the clinical symptoms, reduce the size of uterine fibroids, and reduce the expression of PR and ER in uterine fibroids. This method is safe and effective and worth exploring and studying in clinic.