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[目的]探讨诱导化疗联合放疗和辅助化疗治疗中晚期鼻咽癌的疗效。[方法]65例中晚期鼻咽癌分为治疗组45例,采用放疗前诱导化疗1次+根治性放疗+辅助化疗3～5次;对照组20例,行单纯行根治性放疗。化疗方案为氟尿嘧啶(5-Fu)0.5g/m2,d1～3;表柔比星(EPI)60mg/m2,d1;顺铂(DDP)30mg/m2,d1～3;静脉滴注。两组放疗方法、时间和剂量分割均相同。[结果]治疗组与对照组3年无瘤生存率分别为71.0%、35.0%(P<0.05),远处转移率分别为46.7%、75.0%(P<0.05)。无不可耐受的毒副反应发生。[结论]诱导化疗联合放疗和辅助化疗治疗局部中晚期鼻咽癌能提高生存率,降低远处转移率。
[Objective] To evaluate the efficacy of induction chemotherapy combined with radiotherapy and adjuvant chemotherapy in the treatment of advanced nasopharyngeal carcinoma. [Method] 65 cases of advanced nasopharyngeal carcinoma were divided into treatment group (n = 45), induction chemotherapy before radiotherapy + radiotherapy + adjuvant chemotherapy for 3 ~ 5 times and control group (n = 20). The chemotherapy regimen was 5-Fu 0.5g / m2, d1-3; epirubicin (EPI) 60mg / m2, d1; DDP 30mg / m2, d1-3; Radiotherapy methods, time and dose of the two groups were the same. [Results] The three-year disease-free survival rates of the treatment group and the control group were 71.0% and 35.0%, respectively (P <0.05). The distant metastasis rates were 46.7% and 75.0% respectively (P <0.05). No unbearable side effects occur. [Conclusion] Induction chemotherapy combined with radiotherapy and adjuvant chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma can improve the survival rate and reduce the distant metastasis rate.