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目的 :探讨毒结清制剂配合肝动脉化疗栓塞(TACE)治疗中晚期肝癌的疗效。方法 :将60例中晚期原发性肝癌患者随机分为两组。治疗组30例,以毒结清制剂配合TACE治疗,对照组30例,行单纯TACE治疗。结果 (:1)两组有效率分别为70%和46.7%,缓解率为83.3%和60%。两组有效率比较无显著性差异(P>0.05),缓解率比较有统计学意义(P<0.05)(;2)两组治疗前后AFP均有不同程度降低,比较均有显著性差异(P<0.05),对于AFP>400 ng/mL,治疗组较对照组下降幅度较明显,比较有显著性差异(P<0.05);(3)治疗组治疗后1周、1个月血管内皮生长因子(VEGF)水平均低于对照组(P<0.05);(4)总胆红素在术后1周比较有显著性差异(P<0.05)。两组患者的ALT、AST术后1 d治疗组较对照组升高幅度较少(P<0.05),术后1周治疗组较对照组下降明显,比较有统计学意义(P<0.05)。结论 :毒结清制剂配合TACE治疗中晚期原发性肝癌,其疗效明显优于单纯TACE治疗,既能抗肿瘤,又能减少TACE引起的不良反应,还可以一定程度抑制血管生成,预防肿瘤复发转移。
Objective: To investigate the curative effect of drug-binding clearing-point preparation combined with transcatheter arterial chemoembolization (TACE) in the treatment of advanced liver cancer. Methods: Sixty patients with advanced primary liver cancer were randomly divided into two groups. Thirty patients in the treatment group were treated with Tox combined with TACE and 30 in the control group with TACE alone. Results (1) The effective rates of the two groups were 70% and 46.7% respectively, and the response rates were 83.3% and 60% respectively. There was no significant difference between the two groups (P> 0.05), and the remission rate was statistically significant (P <0.05) (; 2) The AFP in both groups decreased to some extent before and after treatment, with significant difference <0.05). For AFP> 400 ng / mL, the decrease in the treatment group was more significant than that in the control group (P <0.05); (3) The levels of vascular endothelial growth factor (P <0.05). (4) The total bilirubin had a significant difference at 1 week after operation (P <0.05). The ALT and AST levels in the two groups were significantly lower than those in the control group (P <0.05), and the levels of ALT and AST decreased significantly in the first week after operation compared with the control group (P <0.05). Conclusion: Toxoplasma gondii combined with TACE in the treatment of advanced primary hepatocellular carcinoma is more effective than TACE alone in anti-tumor and TACE-induced adverse reactions. It can also inhibit angiogenesis and prevent tumor recurrence to a certain extent Transfer.