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目的探讨呼气末二氧化碳分压(PETCO2)与动脉二氧化碳分压(PaCO2)在不同疾病婴幼儿机械通气中的相关性。方法 58例1～36个月机械通气的婴幼儿按病种不同分为无心肺功能异常、各种原因导致肺部疾病两组。用主流式PETCO2监测模块于气管导管近端连续监测PETCO2,在呼吸机通气1h后患儿安静状态下抽动脉血进行血气分析并记录即刻PETCO2,计算PaCO2与PETCO2差ADCO2,分别进行相关性统计处理。结果机械通气治疗1h后第一组患者PETCO2为(34.32±4.62)mmHg,PaCO2为(35.79±3.44)mmHg,ADCO2为(2.50±1.02)mmHg;PETCO2与PaCO2间相关系数r为0.819,P<0.01;第二组患者PETCO2为(36.3±5.1)mmHg,PaCO2为(41.8±6.5)mmHg,ADCO2为(4.17±2.11)mmHg;PETCO2与PaCO2间相关系数r为0.605,P<0.05。结论在婴幼儿各类疾病进行机械通气时,PETCO2与PaCO2均有良好的相关性,提示PETCO2可粗略反映机械通气状态下PaCO2的变化,无肺部病变者二者相关性更好。
Objective To investigate the correlation between PETCO2 and PaCO2 in mechanical ventilation of infants and young children with different diseases. Methods 58 cases of 1 ~ 36 months of mechanical ventilation infants and young children were divided into different types of non-cardiopulmonary dysfunction, a variety of causes of lung disease in both groups. PETCO2 was continuously monitored at the proximal end of the tracheal tube with the mainstream PETCO2 monitoring module. Blood was collected by twitching blood gas in the quiet state of the ventilator for 1 hour and the immediate PETCO2 was recorded. The difference between the PaCO2 and PETCO2 ADCO2 was calculated and statistically analyzed respectively . Results After 1h of mechanical ventilation, PETCO2 in the first group was (34.32 ± 4.62) mmHg, PaCO2 was (35.79 ± 3.44) mmHg, ADCO2 was (2.50 ± 1.02) mmHg in the first group. The correlation coefficient between PETCO2 and PaCO2 was 0.819 (36.3 ± 5.1) mmHg in the second group, (41.8 ± 6.5) mmHg in PaCO2, and (4.17 ± 2.11) mmHg in ADCO2. The correlation coefficient r between PETCO2 and PaCO2 was 0.605, P <0.05. Conclusions PETCO2 has good correlation with PaCO2 in various diseases of infants and young children, suggesting that PETCO2 can roughly reflect the change of PaCO2 under mechanical ventilation, and the correlation between PETCO2 and PaCO2 is better.