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大鼠口服~3H-天麻素后,胃肠道放射性消失很快,8h仅剩给药后即刻放射性的1.1％。口服后5min血中放射性已有较高水平,50min左右达高峰。静注或口服后,组织放射性均以肾最高。肝、肺、子宫其次。脑中放射性较低,但变化不同于其他组织,2h达高峰。天麻素血浆蛋白结合率为4.3％,其甙元(对羟基苯甲醇)为69.3％。天麻素在体内主要代谢物是甙元。口服后放射性主要从尿排泄。口服后24h内从尿、粪和胆汁排出的总放射性分别为剂量的66.1,0.63和3.06％
After oral administration of ~ 3H-gastrodin in rats, the radioactivity of gastrointestinal tract disappeared quickly, and the remaining radioactivity was 1.1% immediately after 8h administration. 5min after oral radioactive blood has a higher level, reaching a peak around 50min. After intravenous or oral administration, tissue radioactivity are the highest in the kidney. Liver, lung, uterus followed. Low radioactive brain, but the change is different from other organizations, reached the peak at 2h. Gastrodin plasma protein binding rate of 4.3%, aglycone (p-hydroxybenzyl alcohol) was 69.3%. Gastrodin in the body is the main metabolite aglycone. After oral radioactive urine excretion. The total radioactivity excreted from urine, feces and bile within 24 hours after oral administration was 66.1, 0.63 and 3.06% of the dose, respectively