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在嘌呤的第九位上引入烃基的氮芥侧链可得化合物Ⅲ,Ⅴ,Ⅷ,该类化合物可与核糖或去氧核糖相联、以形成相应的RNA或DNA。实驗指出、次黃嘌呤衍生物(Ⅴ)经試驗动物治疗具有較广泛的抗肿瘤效果。
The addition of a hydrocarbon-based nitrogen mustard side chain to the 9th position of the purine results in compounds III, V and VIII which can be linked to ribose or deoxyribose to form the corresponding RNA or DNA. Experiments show that hypoxanthine derivatives (Ⅴ) treated animals have a broader anti-tumor effect.