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目的分析2012年六安市手足口病的病原构成情况,为科学防治手足口病提供实验室依据。方法对2012年六安市各县区疾控中心送检的271份手足口病病例的咽拭子标本,用RT-PCR进行肠道病毒71型(Enterovirus 71,EV71)、柯萨奇病毒A组16型(Cox A16)和其它及肠道病毒核酸检测。结果 2012年全年共检测手足口病病例标本271份,检出人肠道病毒核酸阳性132份,总阳性率为48.71%。其中EV71核酸阳性82份,占62.12%;Cox A16核酸阳性28份,占21.21%;非EV71、非Cox A16的其他肠道病毒核酸阳性22份,占16.67%。132份阳性标本中4岁以下113份,占85.61%。病原检测阳性率在1月、5月和9月出现3次高峰。结论 2012年六安市手足口病最主要病原为EV71,4岁以下儿童为主要易感人群,应加强对4岁以下儿童手足口病的病原学监测。
Objective To analyze the pathogenic constitution of HFMD in Lu’an City in 2012 and provide laboratory evidence for the scientific prevention and treatment of HFMD. Methods A total of 271 throat swab specimens of HFMD cases were collected from all districts and counties in Lu’an City in 2012. RT-PCR was performed for Enterovirus 71 (EV71), Coxsackievirus A Group C (Cox A16) and other and enterovirus nucleic acid tests. Results A total of 271 hand-foot-mouth disease cases were detected in 2012. The positive rate of human enterovirus nucleic acid was 132, with a total positive rate of 48.71%. Among them, 82 were positive for EV71 nucleic acid, accounting for 62.12%; 28 were positive for Cox A16 nucleic acid, accounting for 21.21%; 22 were non-EV71 and non-Cox A16 positive for other enterovirus nucleic acid, accounting for 16.67%. Among 132 positive samples, 113 were below 4 years old, accounting for 85.61%. The positive rate of pathogen detection in January, May and September there were 3 peaks. Conclusion The most common pathogen of HFMD in Lu’an City in 2012 is EV71. Children under 4 years of age are the predominant susceptible population. Etiological surveillance of HFMD in children under 4 years of age should be strengthened.