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目的：观察国产重组人粒细胞集落刺激因子（吉粒芬）预防肿瘤化疗所致的白细胞减少及其不良反应。方法：对１３６例经病理确诊的恶性肿瘤患者，于化疗后２４ｈ给予吉粒芬７５μｇ／ｄ，ｓｃ，连用１０ｄ，或当中性粒细胞绝对数（ＡＮＣ）降至最低值后回升超过５×１０９／Ｌ达２次以上停药。结果：化疗后平均ＡＮＣ最低值为（２．１８±１．３８）×１０９／Ｌ；平均ＡＮＣ减少持续天数（Ｉ，ＩＩ，ＩＶ度）分别是（１．５６±２．０４），（０．４５±１．３０）和（０．０４±０．３６）ｄ；平均ＡＮＣ减少的发生率分别为５４．４１％，１６．１８％和２．２１％。不良反应有轻度骨痛或肌痛、乏力。结论：吉粒芬可减轻化疗后ＡＮＣ降低程度，缩短ＡＮＣ减少的持续时间，促进ＡＮＣ的恢复，降低感染发热的发生机会，无明显毒副反应，可作为肿瘤化疗中有价值的辅助药物。
Objective: To observe the effect of domestic recombinant human granulocyte colony-stimulating factor (Ji-Li-Fen) on leukopenia induced by chemotherapy and its adverse reactions. Methods: Thirty-six patients with pathologically diagnosed malignant tumor were treated with gemfibrozil at 75μg / d for 24 hours after chemotherapy, scaled for 10 days or returned to more than 5 × 109 after the neutrophil absolute number (ANC) / L up to 2 times or more withdrawal. Results: The lowest mean ANC after chemotherapy was (2.18 ± 1.38) × 109 / L, and the mean duration of ANC reduction was (1.56 ± 2.04) and (0 .45 ± 1.30) and (0.04 ± 0.36) d respectively. The mean ANC reduction rates were 54.41%, 16.18% and 2.21%, respectively. Adverse reactions with mild bone pain or myalgia, fatigue. Conclusion: Jiguanfen can reduce the degree of ANC reduction after chemotherapy, shorten the duration of ANC reduction, promote the recovery of ANC, reduce the incidence of fever, no obvious toxic and side effects, and can be used as valuable adjuvant drugs in tumor chemotherapy.