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目的 观察在低压舱中模拟不同高度是否影响狗餐后和红霉素所致的胃肠收缩活动 ,为阐明飞行因素对胃肠动力的影响提供理论依据。 方法 应用低顺应性毛细管水灌注消化道腔内测压系统记录清醒狗胃和十二指肠的收缩活动。在低压舱地面、模拟升至 30 0 0 m和 5 0 0 0 m高度分别记录狗进食和静脉注射红霉素所致胃肠收缩的变化。 结果 1在模拟 5 0 0 0 m高度状态 ,狗餐后胃窦和十二指肠收缩振幅、收缩频率和动力指数明显低于地面时 (P<0 .0 5 ,P<0 .0 1) ;2在 5 0 0 0 m高度时 ,静脉注射红霉素引起狗胃窦和十二指肠收缩时间、振幅和动力指数也明显降低 (P<0 .0 5 ,P<0 .0 1) ;3模拟 30 0 0 m高度则对狗胃肠收缩无明显影响 ;4在 5 0 0 0 m高度狗的摄食能力也明显降低。 结论 急性暴露于低压低氧抑制了狗餐后和红霉素所致的胃窦和十二指肠收缩 ,这可能是狗摄食能力降低的原因之一
Objective To observe whether simulating different heights in the low-pressure cabin could affect the gastrointestinal contractile activity induced by dog meal and erythromycin, and provide a theoretical basis for clarifying the influence of flight factors on gastrointestinal motility. Methods The contractile activity of awake dogs’ stomach and duodenum was recorded by low conformity capillary water perfusion intraluminal manometry system. On the surface of the low-pressure cabin, the changes of gastrointestinal constriction induced by erythromycin and dog’s diet were recorded when the simulated altitude increased to 300 m and 500 m respectively. Results 1 In simulating the height of 500m, the amplitude of postprandial gastric antrum and duodenal contraction, the frequency of contraction and the dynamic index were significantly lower than those on the ground (P <0.05, P <0.01) ; 2 At 50000 m height, erythromycin intravenously induced contraction of gastric antrum and duodenum in dogs with a significant decrease in amplitude and motor index (P <0.05, P <0.01) ; 3 Simulated 30 0 0 m height had no significant effect on the gastrointestinal contraction of dogs; 4 The feeding ability of dogs at 5 0 0 0 m height was also significantly reduced. Conclusions Acute exposure to hypobaric hypoxia inhibits the contraction of gastric antrum and duodenum induced by postprandial and erythromycin in dogs, which may be one of the reasons for the decreased feeding capacity of dogs