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目的探讨和分析急性酒精中毒急诊应用盐酸纳美芬注射液治疗的临床效果和安全性。方法 50例急性酒精中毒患者作为研究主体,按照患者入急诊的顺序分为乙组(23例)和甲组(27例)。乙组患者通过盐酸纳洛酮进行治疗,甲组患者通过盐酸纳美芬进行治疗。比较两组患者的治疗效果和不良反应情况。结果甲组患者治疗总有效率96.30%高于乙组73.91%,差异具有统计学意义(P<0.05)。两组患者均未发生心律失常、脑水肿、低血压以及呼吸抑制加重等不良反应。结论急性酒精中毒急诊应用盐酸纳美芬注射液治疗的临床效果确切,且安全性高,值得推广。
Objective To investigate and analyze the clinical efficacy and safety of nalmefene hydrochloride injection for emergency treatment of acute alcoholism. Methods Fifty patients with acute alcoholism were divided into two groups: group B (23 cases) and group A (27 cases), according to the sequence of emergency treatment. Patients in group B were treated with naloxone hydrochloride and patients in group A were treated with nalmefene hydrochloride. The treatment effect and adverse reaction of two groups were compared. Results The total effective rate of treatment group A was 96.30% higher than that of group B 73.91%, the difference was statistically significant (P <0.05). Two groups of patients did not occur arrhythmia, cerebral edema, hypotension and respiratory depression and other adverse reactions. Conclusion Acute alcoholism emergency nalmefene hydrochloride injection treatment of clinical effect is exact, and high safety, it is worth promoting.