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目的探讨卵巢恶性上皮性肿瘤中ｐ５３和ｃ┐ｅｒｂＢ┐２基因表达与肿瘤恶性程度和预后的关系。方法１０８例卵巢癌应用Ｓ┐Ｐ免疫组化法检测其ｐ５３和ｃ┐ｅｒｂＢ┐２基因产物，另有１０例卵巢良性上皮性肿瘤作为对照。结果在１０例卵巢良性上皮性肿瘤中，ｐ５３和ｃ┐ｅｒｂＢ┐２产物均为阴性，在３７例交界性肿瘤中，其阳性率分别为２９．７％和２４．３％，７１例卵巢癌则高达５０．７％和５３．５％。在卵巢癌的不同组织学类型中，粘液性癌ｐ５３产物的阳性率高于浆液性和内膜样癌。在肿瘤分化方面，低分化癌的阳性率明显高于高分化癌组。在随访３～１４年的５６例中，ｐ５３和ｃ┐ｅｒｂＢ┐２基因的表达分别为２６．１％和２８．６％，明显低于死亡组（６６．７％和７７．８％），其差别是很明显的。结论上述结果表明，ｐ５３和ｃ┐ｅｒｂＢ┐２基因在卵巢恶性上皮性肿瘤中高表达，则其生物学行为和预后均较差。
Objective To investigate the relationship between the expression of p53 and c┐erbB┐2 gene and the malignancy and prognosis of malignant ovarian epithelial tumors. Methods 108 cases of ovarian cancer were examined by immunohistochemical staining for p53 and c┐erbB┐2 gene products, and another 10 cases of ovarian benign epithelial tumors served as controls. Results In 10 cases of ovarian benign epithelial tumors, p53 and c┐erbB┐2 products were negative. Among 37 borderline tumors, the positive rates were 29.7% and 24.3%, respectively, and 71 cases of ovarian cancer. It is as high as 50.7% and 53.5%. In different histological types of ovarian cancer, the positive rate of p53 product in mucinous carcinoma is higher than serous and endometrioid carcinoma. In tumor differentiation, the positive rate of poorly differentiated cancer was significantly higher than that of well-differentiated cancer group. In 56 cases followed up for 3 to 14 years, the expression of p53 and c┐erbB┐2 genes was 26.1% and 28.6%, respectively, which was significantly lower than that of the death group (66.7% and 77.8%). The difference is obvious. Conclusions The above results indicate that the high expression of p53 and c┐erbB┐2 genes in malignant epithelial ovarian tumors leads to poor biological behavior and poor prognosis.