论文部分内容阅读
目的:探讨母亲孕早期精神刺激与子代先天性心脏病(CHD)的关系。方法:抽取2012年1月~2014年1月在湖北省武汉市区级妇幼保健机构进行CHD免费筛查、通过常规的听诊及超声心动图筛出、并经市级以上医院确诊的201例CHD患儿为病例组,按照年龄、性别及社区配对选择402例健康婴儿为对照组。用Epi Data 3.1软件录入数据,用SPSS 22.0软件进行单因素和多因素分析。结果:对母亲孕早期精神刺激进行单因素分析,结果显示:孕早期精神刺激与子代CHD的发生有一定关联(χ2=21.6866,P<0.000 1,OR=9.716,95%CI:3.731~25.299);多因素分析结果显示:孕早期精神刺激(P=0.0038,OR=5.986,95%CI:1.781~20.118)是CHD的危险因素之一。结论:孕早期精神刺激对子代CHD的发生影响较大。加强围孕期保健、避免负性事件的刺激、让孕母心情保持舒畅可在一定程度上减少CHD的发生。
Objective: To explore the relationship between mothers ’mothers’ early mental stimulation and children’s congenital heart disease (CHD). Methods: From January 2012 to January 2014, free CHD screening was conducted in district-level maternal and child health institutions in Wuhan City, Hubei Province, and routine CHD and echocardiography were performed to screen out 201 CHDs diagnosed by hospitals above the city level Children with case group, according to age, gender and community paired selection of 402 healthy infants as the control group. Data was entered using Epi Data 3.1 software, and univariate and multivariate analyzes were performed using SPSS 22.0 software. Results: Univariate analysis of mothers ’mothers’ mental stimulation during the first trimester showed that there was a correlation between the first trimester mental stimulation and the occurrence of CHD in offspring (χ2 = 21.6866, P <0.0001, OR = 9.716, 95% CI: 3.731-25.299 ). Multivariate analysis showed that mental stimulation (P = 0.0038, OR = 5.986, 95% CI: 1.781-20.118) in early pregnancy was one of the risk factors for CHD. Conclusion: Psychomotor stimulation in early pregnancy has a great impact on the occurrence of CHD in offspring. Strengthen the perinatal care, to avoid the negative events of stimulation, to keep mothers feel comfortable to a certain extent, reduce the occurrence of CHD.