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霉菌在自然界中分布非常广泛,土壤、粮食、食品、空气以至水体中,都可能有各种霉菌及其孢子存在,其中有不少可能是产毒霉菌。许多资料报道产毒霉菌的代谢产物能引起动物过敏、中毒或肿瘤的形成;通过呼吸道或消化道进入机体并诱发一定的病变。有人认为,有一种化学毒剂也属于霉菌代谢产物,称为T-2毒素。因此对产毒霉菌必须引起高度重视。1982年我们从北方地区某部坑道储水表面生长的霉菌中分离出300多株霉菌,经中国科学院微生物所鉴定选出11株进行产毒培养,然后将其代谢产物的粗提物,分别进行豌豆发芽抑制试验和兔子皮肤毒性试验,根据对豌豆发芽的抑制率和兔子皮肤的毒性反应,评价其毒性大小。
Molds are widely distributed in nature. Various molds and their spores may exist in soil, food, food, air and water bodies. Many of them may be mold-producing fungi. Many sources report that metabolites of toxigenic fungi can cause animal allergies, poisoning or tumor formation; they enter the body through the respiratory or gastrointestinal tract and induce certain lesions. Some people think that there is a chemical poison also belong to mold metabolites, called T-2 toxin. Therefore, to produce toxins must be highly valued. In 1982, more than 300 molds were isolated from molds growing on the surface of waterways in a section of tunnels in the northern part of China. Eleven strains were identified and identified by the Institute of Microbiology, Chinese Academy of Sciences. The crude extracts of their metabolites were then separated Pea germination inhibition test and rabbit skin toxicity test, according to the inhibition rate of pea germination and rabbit skin toxicity, evaluate the toxicity of the size.