Aims: To introduce new terminology and validate its reliability for the analys is of optical coherence tomography (OCT) scans, compare clinical detection of cy stoid macular oedema (CMO)and subretinal fluid (SRF) with OCT findings, and to s tudy the effect of photodynamic therapy (PDT) on the foveal morphology. Methods: Patients with subfoveal, predominantly classic choroidal neovascularisation (CN V) secondary to age related macular degeneration (AMD) undergoing PDT were evalu ated with refraction protocol best corrected logMAR visual acuity (VA), slit lam p biomicroscopy, stereoscopic fluorescein angiography (FFA), and OCT. New termin ologies introduced to interpret the OCT scans were: neuroretinal foveal thicknes s (NFT), bilaminar foveal thickness (BFT), outer high reflectivity band thicknes s (OHRBT), intraretinal fluid (IRF), subretinal fluid (oSRF), and vitreomacular hyaloid attachment (VMHA). Results: Fifty six eyes of 53 patients were studied. VA was better in eyes with a thinner outer high reflectivity band (OHRBT) (p=0.0 2) and BFT (p=0.05). BFT was less in eyes that had undergone a greater number of PDT treatments (p=0.04). There was poor agreement between OCT and clinical exam ination in the detection of CMO and subretinal fluid (κ.=0.289 and κ.=0.165 re spectively). To validate the interpretation and measurements on OCT, two groups of 20 scans were analysed by two independent observers. There was good agreement between the observers in the detection of IRF,oSRF, and VMHA (p< 0.001). Measur ements of NFTand BFThad a high reproducibility, and of OHRBT reproducibility was low. Conclusions: New terminology has been introduced and tested. OCT appears t o be superior to clinical examination and FFAin the detection of CMO. In this st udy, better vision was associated with a thinner OHRBT and/or the absence of SRF giving insight into the biological effect of PDT. Aims: To introduce new terminology and validate its reliability for the analys is of optical coherence tomography (OCT) scans, compare clinical detection of cystoid macular oedema (CMO) and subretinal fluid (SRF) with OCT findings, and to investigate the effect Methods: Patients with subfoveal, predominantly classic choroidal neovascularisation (CN V) secondary to age related macular degeneration (AMD) undergoing PDT were evaluated withted refraction protocol best corrected logMAR visual acuity (VA) , late lam p biomicroscopy, stereoscopic fluorescein angiography (FFA), and OCT. New terminologies introduced to interpret the OCT scans were: neuroretinal foveal thicknes s (NFT), bilaminar foveal thickness (BFT), outer high reflectivity band thicknes s ), intraretinal fluid (IRF), subretinal fluid (oSRF), and vitreomacular hyaloid attachment (VMHA). Results: Fifty six eyes of 53 patients were studied. VA was better in eyes with a thin BFT was less in eyes that had undergone a greater number of PDT treatments (p = 0.04). There was poor agreement between OCT and clinical (OHRBT) (p = 0.02) and BFT examining ination in the detection of CMO and subretinal fluid (κ. = 0.289 and κ. = 0.165 re spectively). To validate the interpretation and measurements on OCT, two groups of 20 scans were analysed by two independent observers. There was good agreement between The observers in the detection of IRF, oSRF, and VMHA (p <0.001). Measurments of NFT and BFThad a high reproducibility, and of OHRBT reproducibility was low. Conclusions: New terminology has been introduced and tested. OCT appears to be superior to clinical examination and FFAin the detection of CMO. In this st udy, better vision was associated with a thinner OHRBT and / or the absence of SRF giving insight into the biological effect of PDT.