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目的 探讨西咪替丁对小儿轮状病毒肠炎的临床疗效分析.方法 选择2012年1月-2015年12月收治的150例轮状病毒感染的肠炎患儿,根据随机数字表法,将所有患儿分为观察组与对照组.两组均给予常规治疗,对照组在常规治疗基础上给予利巴韦林用药,观察组在常规治疗基础上给予西咪替丁用药,观察两组患儿平均退热时间、平均止泻时间、平均止吐时间、疗效及不良反应.观察两组治疗前后的IL-2、IL-6及TNF-α水平.结果 观察组的平均退热时间、平均止泻时间、平均止吐时间明显低于对照组,观察组的总有效率明显高于对照组,治疗后两组患儿的IL-6、TNF-α均显著降低,组内对比差异明显,组间对比发现观察组明显低于对照组(P＜0.05);治疗后两组的IL-2均明显升高,组内对比差异明显,组间对比观察组明显高于对照组(P＜0.05).观察组的不良反应率低于对照组,但组间对比无统计学差异(P＞0.05).结论 西咪替丁可通过调节轮状病毒引起的炎症反应,提高治疗总有效率,加快患儿临床症状的恢复,治疗小儿轮状病毒肠炎安全有效,值得临床推广应用.“,”Objective To investigate the clinical effect of cimetidine on rotavirus enteritis in children.Methods From January 2012 to December 2015,150 cases of rotavirus enteritis in our hospital were selected as research objects and they were randomly divided into the observation group and control group.In addition to the conventional treatments for both groups,the control group was given ribavirin and the observation group was given cimetidine.The average recover times from fever,diarrhea and vomiting,as well as efficacy and adverse reaction were recorded and compared.IL-2、IL-6 and TNF-α of both groups were observed and compared.Resuits The average recover times from fever,diarrhea and vomiting of the observation group were lower than that of the control group (P ＜ 0.05).The total efficacy of observation group was higher than that of the control group (P ＜ 0.05).In the observation group,IL-6,TNF-α were lower than that of the control group (P ＜ 0.05) while IL-2 of the observation group was higher than that of the control group (P ＜ 0.05).Conclusions Cimetidine could regulate the inflammatory reaction,and improve the total efficacy,accerate the recovery of clinical symptoms,which is help to children with rotavirus enteritis.