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目的:研究雾化布地奈德或使用抗生素对无基础肺疾患的呼吸机相关性支气管炎(VAT)患者影响。方法:将无基础肺疾患的VAT患者171例随机分为抗生素组、雾化组和对照组,分别给予抗生素、布地德雾化治疗和生理盐水雾化治疗,治疗期7天,观察期3个月,比较各组呼吸机相关性肺炎(VAP)发生率、机通气时间、入住ICU时长及死亡率。结果:抗生素组、雾化组VAP发生率及死亡率均显著低于对照组,P<0.0三组的ICU住院日、呼吸机辅助通气时间均无明显差异(P>0.05)。结论:对无基础肺疾患的VAT患者,雾化入布地奈德或短期使用抗生素能降低其VAP发生率及死亡率。
OBJECTIVE: To study the effects of atomized budesonide or antibiotics on ventilator-associated bronchitis (VAT) patients without underlying lung disease. Methods: A total of 171 patients with VAT without underlying lung disease were randomly divided into antibiotic group, nebulized group and control group. Antibiotics, Bouderhade nebulization and saline nebulization were given respectively. The treatment period was 7 days and the observation period was 3 Month, and compared the incidence of ventilator-associated pneumonia (VAP), ventilatory time, duration of ICU stay and mortality in each group. Results: The incidence of VAP and mortality in the antibiotic group and the atomization group were significantly lower than those in the control group. There was no significant difference in the ICU stay days and ventilator assisted ventilation between the three groups (P <0.05) (P> 0.05). CONCLUSIONS: In patients with VAT without underlying lung disease, either inhalation of budesonide or short-term use of antibiotics can reduce their VAP incidence and mortality.