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目的研究姜黄素固体分散体对二氧化硅(SiO2)染尘大鼠体内氧化水平的影响。方法Wistar大鼠采用非气管暴露法染尘。染尘后给予姜黄素固体分散体干预,大鼠饲养12周,测定大鼠血清及肺组织中超氧化物歧化酶(SOD)活力、丙二醛(MDA)含量,测定大鼠肺灌洗液中乳酸脱氢酶(LDH)和酸性磷酸酶(ACP)的活力。结果与正常对照组比较,实验组大鼠体内SOD活力显著降低,MDA的含量显著升高(P<0.01)。与实验组比较,姜黄素固体分散体能显著降低SiO2染尘大鼠体内MDA的含量(P<0.05),提高SOD活力(P<0.05),提高机体对自由基的清除能力。结论姜黄素固体分散体能显著提高SiO2染尘大鼠抗氧化能力。
Objective To study the effect of curcumin solid dispersion on the oxidation of silica (SiO2) in rats. Methods Wistar rats were dusted by non-tracheal exposure. Curcumin solid dispersion was intervened after dyeing, and rats were fed for 12 weeks. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in rat serum and lung tissue were measured and measured in rat lung lavage fluid. The activity of lactate dehydrogenase (LDH) and acid phosphatase (ACP). Results Compared with the normal control group, the activity of SOD in the experimental group was significantly reduced and the content of MDA was significantly increased (P<0.01). Compared with the experimental group, curcumin solid dispersion can significantly reduce the content of MDA (P<0.05), increase the activity of SOD (P<0.05), and increase the free radical scavenging capacity of the body. Conclusion Curcumin solid dispersion can significantly increase the antioxidant capacity of SiO2 dust-dusted rats.