论文部分内容阅读
目的探讨短期应用奥美拉唑治疗反流性食管炎的疗效及其与CYP2C19基因多态性的关系。方法应用奥美拉唑20mg每日晨起空腹口服1次,持续4周,治疗56例经胃镜证实的反流性食管炎患者。记录治疗前和用药2周后、4周后时症状的变化,并于治疗结束时复查胃镜。受试者CYP2C19的基因型检测采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)分析方法。结果纯合子强代谢组、杂合子强代谢组和弱代谢组胃镜下治愈率分别为47.37%、69.23%和88.89%,纯合子强代谢组的治愈率显著低于弱代谢组(P<0.05)。结论CYP2C19基因多态性与奥美拉唑治疗反流性食管炎的疗效密切相关。CYP2C19基因分型检测是临床治疗酸相关性疾病中的一个重要的工具。
Objective To investigate the efficacy of short-term omeprazole in the treatment of reflux esophagitis and its relationship with CYP2C19 gene polymorphism. Methods Omeprazole 20mg orally taken once daily morning fasting for 4 weeks, 56 patients treated by endoscopy confirmed reflux esophagitis patients. Record before treatment and after 2 weeks of treatment, 4 weeks after the change of symptoms, and at the end of the treatment of gastroscopy review. The genotype of CYP2C19 was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The cure rates of homozygous strong metabolism group, heterozygous strong metabolism group and weak metabolism group were 47.37%, 69.23% and 88.89%, respectively. The cure rate of homozygotic strong metabolism group was significantly lower than that of weak metabolism group (P <0.05) . Conclusion CYP2C19 gene polymorphism and omeprazole treatment of reflux esophagitis is closely related to the efficacy. Genotyping of CYP2C19 is an important tool in the clinical management of acid-related diseases.