左旋千金芚啶碱(l-Stepholidine,以下简称l-SPD)是中国科学院上海药物研究所从防己科植物河谷地不容(Stephania intermedia Lo)中提取的生物碱,为四氢原小檗碱(Tetrahydr-oprotoberberine,ThPB)的同类物,具有中枢多巴胺(DA)受体阻滞剂的作用特征,在整体动物实验时表现有安定、镇痛、镇吐等作用,是一个有研究价值的新药。拟推荐于临床治疗中枢DA功能失调性疾病(例如精神病)以及用于复合麻醉、镇静、镇痛等。本文用放射性核 L-Stepholidine (l-SPD) is an alkaloid extracted from Stephania intermedia Lo by the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. It is known as Tetrahydr -oprotoberberine, ThPB), which has the function of central dopamine (DA) blocker and has the functions of stability, analgesia and antiemetic in the whole animal experiment. It is a new drug with research value. It is recommended for the clinical treatment of central DA dysfunction diseases (such as psychosis) and for combined anesthesia, sedation, analgesia and the like. This article uses radionuclides