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目的:观察草分支杆菌F.U.36联合大剂量维生素C治疗小儿反复呼吸道感染(RRSI)临床疗效。方法:129例RRSI患儿,随机分为对照和治疗Ⅰ、治疗Ⅱ3个组。对照组39例给予青霉素及利巴韦林注射液iv,gtt,bid常规治疗,7～10d为1个疗程;治疗Ⅰ组45例,在上述常规治疗的基础上,同时给予草分枝杆菌F.U.36 1.72μg,深部i m,每周1次,1个月为1个疗程;治疗Ⅱ组45例,在治疗Ⅰ组的基础上,同时根据体质量大小分别给予维生素C3～5g.d-1,5d为1个疗程。观察3组疗效,并测定IgA、IgG、Ig M、CD3+、CD4+、CD8+、CD4+/CD8+的水平。结果:3组的总有效率分别为51.3%(20/39),84.4%(37/45),93.3%(42/45),3组比较差异有显著及极显著性(P<0.05或P<0.01)。治疗组治疗后,IgA、IgG、Ig M、CD3+、CD4+、CD8+、CD4+/CD8+值均明显增加(P<0.05或P<0.01)。结论:草分支杆菌F.U.36与大剂量维生素C联合应用防治小儿RRSI有明显疗效,能有效地改善免疫学指标,无明显不良反应。
Objective: To observe the clinical efficacy of Mycobacterium phlei F.U.36 combined with high-dose vitamin C in the treatment of children with recurrent respiratory tract infection (RRSI). Methods: 129 children with RRSI were randomly divided into control and treatment Ⅰ, treatment Ⅱ 3 groups. 39 cases of control group were given penicillin and ribavirin injection iv, gtt, bid routine treatment, 7 ~ 10d for a course of treatment; treatment group Ⅰ 45 cases, on the basis of the above conventional treatment, while given Mycobacterium phlei FU 36 1.72μg, deep im, once a week, 1 month for a course of treatment; 45 cases of treatment group Ⅱ, on the basis of the treatment group Ⅰ, at the same time according to body weight were given vitamin C3 ~ 5g.d-1, 5d for a course of treatment. The effects of three groups were observed and the levels of IgA, IgG, Ig M, CD3 +, CD4 +, CD8 + and CD4 + / CD8 + were measured. Results: The total effective rates of the three groups were 51.3% (20/39), 84.4% (37/45) and 93.3% (42/45), respectively. The differences between the three groups were significant and significant (P <0.05 or P <0.01). After treatment, IgA, IgG, IgM, CD3 +, CD4 +, CD8 + and CD4 + / CD8 + all increased significantly (P <0.05 or P <0.01). Conclusion: Mycobacterium tuberculosis F.U.36 combined with high-dose vitamin C in children with RRSI has obvious curative effect, can effectively improve the immunological parameters, no obvious adverse reactions.