论文部分内容阅读
目的探讨β受体阻滞剂对盐酸去甲乌药碱对心率、血压作用的影响;以及冠状动脉狭窄后药物负荷实验结果。方法10只中华小型猪,随机分别注射选择性β1受体阻滞剂酒石酸美托洛尔、非选择性β受体全阻滞剂普萘洛尔部分或完全阻断β受体后,再注射盐酸去甲乌药碱,记录试验猪的心率、血压的变化;并与单独注射盐酸去甲乌药碱时心率、血压变化进行比较。试验猪造成慢性冠状动脉狭窄模型后,进行盐酸去甲乌药碱药物负荷试验,静态心肌SPECT显像。结果在基础状态,静脉注射盐酸去甲乌药碱后,试验猪平均心率最大增加(40±17)次·min-1(P<0.001),平均收缩压变化没有统计学差异,而平均舒张压最大变化(20±16)mmHg(P=0.0035)。美托洛尔β1受体和普萘洛尔全β受体阻断后,试验猪平均心率最大增加分别为(27±17)和(8±9)次·min-1,与基础状态相比,差异有统计学意义(分别为P=0.0003和P=0.0221)。冠状动脉狭窄猪的心率在药物负荷后心率增加有统计学意义(P<0.05)。应用盐酸去甲乌药碱负荷试验放射性核素心肌显像,检测冠状动脉病变的敏感性约为90%。结论本试验结果提示,盐酸去甲乌药碱可能部分通过β受体发挥其在心血管系统的作用,并可被β受体阻滞剂所部分阻断;作为负荷药物可用于心肌灌注显像中检测冠状动脉狭窄和心肌缺血。
Objective To investigate the effect of β-blocker on the effects of norfloxacin hydrochloride on heart rate and blood pressure, and the drug load after coronary artery stenosis. Methods Ten Chinese miniature pigs were randomized to receive metoprolol, a selective β1-blocker, and propranolol, a blocker of the non-selective β-receptor, partially or completely blocked the β-receptor. Hydrochloric acid desmethione, record the changes of heart rate and blood pressure in pigs, and compare with the heart rate and blood pressure of single injection of norcodine hydrochloride. After the experimental pig caused the model of chronic coronary artery stenosis, the normoxic drug loading test and static myocardial SPECT imaging were performed. Results In the basal state, the average heart rate of test pigs increased by 40 ± 17 times · min-1 (P <0.001) after intravenous injection of norfloxacin hydrochloride, and the mean systolic blood pressure did not change statistically. The mean diastolic blood pressure The maximum change (20 ± 16) mmHg (P = 0.0035). After the block of metoprolol β1 receptor and propranolol all β receptor, the maximum increase of average heart rate in test pigs was (27 ± 17) and (8 ± 9) min-1, respectively. Compared with the basal state , The difference was statistically significant (P = 0.0003 and P = 0.0221, respectively). The heart rate of coronary stenosis pigs increased significantly after drug loading (P <0.05). Application of norfloxacin hydrochloride load test radionuclide myocardial imaging, detection of coronary artery disease sensitivity of about 90%. Conclusions The results of this study suggest that norfloxacin may exert its effects on the cardiovascular system partly through beta receptors and may be partly blocked by beta blockers. It may be used as a loading drug in myocardial perfusion imaging Detection of coronary artery stenosis and myocardial ischemia.