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Seven novel platinum(Ⅱ) complexes [Pt(Ⅱ)(NH_3)(CH_3NH_2)X_2](Ⅰ—Ⅶ)(X: CH_3COO -, CH_2ClCOO-, CHCl_ 2COO -, C_ 6H_ 5—COO -, p-CH_ 3O—C_ 6H_ 4—COO -, p-NH_ 2—C_ 6H_ 4—COO -, p-NO_ 2—C_ 6H_ 4—COO -) were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV, and 1H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin>Ⅳ>Ⅴ>Ⅵ>Ⅶ>Ⅰ>Ⅱ>Ⅲ. Moreover, the complexes( Ⅰ—Ⅶ) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G_ 2/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.
Seven novel platinum (Ⅱ) complexes [Pt (Ⅱ) (NH_3) (CH_3NH_2) X_2] (X-CH_3COO -, CH_2ClCOO-, CHCl_2COO -, C_6H_5-COO - C_6H_4-COO “, p-NH_2-C_6H_4-COO”, p-NO_2_C_6H_4-COO ") were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV , and 1H NMR spectrometry. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin> IV> V> VI> VII> I> II> III Moreover, the complexes (Ⅰ-Ⅶ) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce concentration-dependent accumulation of HL-60 cells in the G_ 2 / M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.