Coordination of Schwann cell myelination and node formation at the transcriptional level

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Formation of the node of Ranvier as a highly coordinated event:Saltatory conduction ensures that information in the vertebrate nervous system is rapidly transmitted over large distances and efficiently processed in complex networks.It requires the insulation of axonal segments by myelin and the formation of highly structured nodes of Ranvier that are interspersed at regular intervals between successive myelin sheaths and regenerate the action potential as it propagates along the nerve(Rasband and Peles,2021).
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