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采用免疫组织化学ＳＰ法分别对５７例宫颈癌、８例慢性宫颈炎ｐ５３蛋白表达情况进行了检测，并以１１例正常宫颈鳞状上皮组织作对照。结果∶ｐ５３蛋白在宫颈癌、慢性宫颈炎中的表达率分别为７８．９％、３７．５％。正常对照均为阴性。ｐ５３蛋白的表达率在宫颈癌病理Ⅲ级中明显高于病理Ⅰ、Ⅱ级（Ｐ＜０．０５）；在溃疡型中的表达率明显低于菜花型、结节型（Ｐ＜０．０５）。提示∶ｐ５３蛋白在慢性宫颈炎中的表达与细胞增殖率升高有关；ｐ５３蛋白的表达率不仅与癌细胞的分化程度有关，而且与宫颈癌的大体分型有关。
The expression of p53 protein in 57 cases of cervical cancer and 8 cases of chronic cervicitis were detected by immunohistochemical SP method, and 11 cases of normal cervical squamous epithelium were used as controls. Results: The expression rates of p53 protein in cervical cancer and chronic cervicitis were 78.9% and 37.5% respectively. Normal controls were negative. The expression rate of p53 protein in pathological grade Ⅲ of cervical cancer was significantly higher than that in pathological grade Ⅰ and Ⅱ (P <0.05), while the expression rate of p53 in ulcer type was significantly lower than that in cauliflower type and nodule type ). Tip: p53 protein in chronic cervicitis expression and cell proliferation rate; p53 protein expression rate not only with the degree of differentiation of cancer cells, but also with the general classification of cervical cancer.