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目的 :观察胸腔内注射山莨菪碱 ( 65 4 Ⅱ )对结核性胸腔积液的临床疗效。方法 :初治的有中等量以上的结核性胸腔积液患者 5 6例 ,随机分为治疗组 3 1例和对照组 2 5例 ,两组抗结核方案相同 ,均予以抽胸腔积液 ,治疗组在抽腔腔积液后注入 65 4 Ⅱ3 0mg ,比较两组的疗效。结果 :治疗组胸腔穿刺次数较对照组少 ( P <0 0 5 ) ,胸腔积液完全吸收时间较对照组显著缩短 (P <0 0 5 ) ,肺功能指标明显优于对照组 (P <0 0 5 ) ;治疗组用药后胸膜厚度 0 5 8± 1 0cm较用药前 0 93± 0 15cm减轻 (P <0 0 5 ) ,治疗组用药后胸腔积液中的蛋白含量、白细胞数、纤维蛋白溶酶原激活物抑制物 1(PAI 1)含量较用药前明显下降 (均为P <0 0 5 )。结论 :胸腔内注射 65 4 Ⅱ有缩短结核性胸腔积液的疗程 ,减轻胸膜肥厚和粘连的作用。
Objective: To observe the clinical effect of intrathoracic injection of anisodamine (65 4 Ⅱ) on tuberculous pleural effusion. Methods: Fifty-six newly diagnosed patients with moderate tuberculosis pleural effusion were randomly divided into treatment group (31 cases) and control group (25 cases). Both groups had the same anti-tuberculosis program, Group in the cavity effusion after injection of 654 Ⅱ3 0mg, the efficacy of the two groups were compared. Results: The number of thoracentesis in treatment group was less than that in control group (P <0 05), and the time of complete absorption in pleural effusion was significantly shorter than that in control group (P 0 05) (P <0.05). After treatment, the thickness of the pleura in the treatment group (0 58 ± 10 cm) was significantly lower than that before treatment (0 93 ± 0 15 cm) (P 0 05). The protein content in the pleural effusion, leukocyte count, fibrin The content of PAI 1 decreased significantly (P <0.05) before treatment. Conclusion: Intrathoracic injection of 65 4 Ⅱ has a shortened course of tuberculous pleural effusion to reduce pleural hypertrophy and adhesion.