奈多罗米钠(Nedocromil sodium,NS)为一种吡喃喹啉二羧酸衍生物,是治疗可逆性阻塞性气道疾病的新疗法。有几项双盲研究已表明NS 对支气管哮喘的疗效。NS 在体外有抑制各种炎性细胞活动的抗炎性质,影响哮喘的发病机制。而且已证明NS 对二氧化硫、神经激肽和P 物质引起的支气管狭窄有抑制作用。在哮喘患者,NS 还能阻断抗原诱发的速发和迟发反应。动物试验表明NS 可减轻枸橼酸引起狗气管切 Nedocromil sodium (NS), a pyranquinoline dicarboxylic acid derivative, is a new treatment for reversible obstructive airways disease. Several double-blind studies have shown the efficacy of NS on bronchial asthma. NS in vitro inhibit the activity of various inflammatory cell anti-inflammatory properties, affecting the pathogenesis of asthma. It has also been demonstrated that NS inhibits bronchoconstriction induced by sulfur dioxide, neurokinin and substance P In asthmatics, NS also blocks antigen-induced immediate and late reactions. Animal experiments show that NS can reduce the citric acid caused by tracheotomy