论文部分内容阅读
目的:探讨不同剂量米非司酮治疗妇科子宫肌瘤的临床疗效。方法:整取抽样我院2013年1月-2016年1月来妇科就诊并确诊为子宫肌瘤患者200例,按随机数字表法分为2组,对照组100例,给予25mg米非司酮治疗,观察组100例,给予12.5mg米非司酮治疗,治疗12周后,观察两组用药效果,测量子宫肌瘤体积变化,同时测定两组血清中雌二醇(E2)、卵泡雌激素(FSH)、孕激素(P)、黄体生成素(LH)等孕激素水平变化,并统计其不良反应发生率。结果:观察组用药总有效率高于对照组(P<0.05);两组用药后子宫肌瘤体积较用药前明显缩小(P<0.05);但两组用药前后子宫肌瘤体积变化无统计学意义(P>0.05);对照组用药后E2、FSH、P、LH水平均低于观察组(P<0.05);但观察组用药不良反应发生率低于对照组(P<0.05)。结论:对子宫肌瘤采取小剂量米非司酮治疗的疗效较好,具有安全、经济、不良反应少等优点。
Objective: To investigate the clinical efficacy of different doses of mifepristone in the treatment of gynecologic uterine fibroids. Methods: In our hospital from January 2013 to January 2016, 200 cases of gynecological patients diagnosed as uterine fibroids were randomly divided into two groups according to random number table method and 100 cases of control group with 25 mg of mifepristone 100 cases in the treatment group and the observation group were treated with 12.5 mg mifepristone. After 12 weeks of treatment, the effect of the two groups was observed and the changes of the volume of the uterine fibroids were observed. The levels of estradiol (E2), follicular estrogen (FSH), progesterone (P) and progesterone (LH), and the incidence of adverse reactions was calculated. Results: The total effective rate of the observation group was higher than that of the control group (P <0.05). The volume of uterine fibroids in the two groups was significantly reduced (P <0.05) before and after treatment, but there was no statistical difference in the volume of uterine fibroids (P <0.05). The levels of E2, FSH, P and LH in the control group were lower than those in the observation group (P <0.05), but the incidence of adverse reactions in the observation group was lower than that of the control group (P <0.05). Conclusion: The treatment of uterine fibroids with low-dose mifepristone has good curative effect, which is safe, economical and has few adverse reactions.