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本文作者测定了正常人和长期接受地高辛治疗的尿毒症和无尿毒症病人的血清镁浓度。在接受地高辛治疗的无尿毒症病人,其血清镁浓度的平均水平明显低于对照组。不论其肾功能如何,约25%接受地高辛治疗的病人有低镁血症。接受地高辛治疗具有肾功能损害者,27%有高镁血症,23%有低镁血症。临床医生处理接受地高辛治疗的病人时,应该知道这一人群出现低镁血症的频繁发病率。因为镁起有Na,K-ATP 酶激活剂的作用,低镁血症可能与毛地黄中毒症状是有关。
The authors determined serum magnesium concentrations in uremic and non uremic patients treated with digoxin in both normal and long-term populations. In patients without uremia treated with digoxin, the average serum magnesium concentration was significantly lower than the control group. About 25% of patients treated with digoxin have hypomagnesemia regardless of their renal function. Digoxin treatment with impaired renal function, 27% had hypermagnesemia, 23% had hypomagnesemia. Clinicians treating patients treated with digoxin should be aware of the frequent incidence of hypomagnesemia in this population. Because magnesium plays a role in Na, K-ATPase activators, hypomagnesemia may be related to symptoms of foxglobulinemia.