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红霉素在碱性环境中抗菌效能较强,当pH低于4时抗菌效能大部分消失。维生素C(VC)是一个酸性药物,不少人把红霉素片与VC片同服视为配伍不合理。我们认为证据不足。 1.临床使用的红霉素片都包有肠溶衣,对酸有相当抵抗力,在小肠崩解。VC片则在胃中崩解,两药崩解部位不同,崩解时间也不同,因此虽同服,但在末
Erythromycin has strong antibacterial activity in alkaline environment, when pH is below 4, most of the antibacterial efficacy disappears. Vitamin C (VC) is an acidic drug, many people with the erythromycin tablets and VC tablets with the same service as unreasonable. We do not think the evidence is sufficient. 1. Clinical use of erythromycin tablets are packaged with enteric coating, the acid is quite resistant to disintegration in the small intestine. VC tablets in the stomach disintegration, disintegration of two different parts of the disintegration time is also different, so although the service, but at the end