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目的探讨供精人工授精(AID)助孕后的妊娠结局及其安全性。方法对2007年3月至2010年4月在广东省计划生育专科医院AID助孕成功妊娠的1102例1134个周期的临床资料进行总结。结果自然流产发生率为14.11%(160/1134),其中生化妊娠流产占20.00%(32/160),临床妊娠流产占80.00%(128/160)。随着年龄的增加,自然流产的发生率呈逐渐上升趋势(P=0.001)。异位妊娠发生率为1.32%(15/1134),妊娠中晚期引产发生率为0.88%(10/1134)。多胎发生率为2.73%(31/1134),其中三胎占12.90%(4/31),双胎占87.10%(27/31)。726例分娩,其中单胎占97.66%(709/726),双胎占2.34%(17/726),分娩方式中顺产自然分娩占42.15%(306/726),剖宫产占57.85%(420/726)。出生新生儿743个,男婴占50.87%(378/743),女婴占49.13%(365/743),男女性别比为104∶100。新生儿出生体重(3180±480)g,出生孕周(39.15±1.43)周。低出生体重儿占6.73%(50/743),巨大胎儿2.69%(20/743),早产儿4.17%(31/743)。出生缺陷发生率为1.74%(13/748)。结论女性年龄是AID妊娠重要影响因素。AID助孕在自然流产、异位妊娠、妊娠分娩、子代出生缺陷和健康状况等方面和自然受孕相似,是一项安全可靠的辅助生殖技术。
Objective To investigate the pregnancy outcome and safety of artificial insemination (AID) for pregnancy. Methods From March 2007 to April 2010, the clinical data of 1,102 cases of 1134 cycles of successful pregnancy with AID in Guangdong Family Planning Specialized Hospital were summarized. Results The incidence of spontaneous abortion was 14.11% (160/1134), of which, biochemical pregnancy miscarriage accounted for 20.00% (32/160) and clinical pregnancy miscarriage accounted for 80.00% (128/160). With increasing age, the incidence of spontaneous abortion increased gradually (P = 0.001). The incidence of ectopic pregnancy was 1.32% (15/1134), and the incidence of induced labor in the second trimester of pregnancy was 0.88% (10/1134). The incidence of multiple births was 2.73% (31/1134), of which 12.90% (4/31) were third births and 87.10% (27/31) were twins. 726 cases were delivered, of which 97.66% (709/726) were singletons, 2.34% (17/726) were twins, 42.15% (306/726) were spontaneous labor during childbirth, and 57.85% / 726). 743 newborns were born, 50.87% (378/743) were male babies, 49.13% (365/743) were female babies, and the male / female ratio was 104: 100. Neonatal birth weight (3180 ± 480) g, gestational age at birth (39.15 ± 1.43) weeks. Low birth weight children accounted for 6.73% (50/743), macrosomia 2.69% (20/743), premature children 4.17% (31/743). The incidence of birth defects was 1.74% (13/748). Conclusion Female age is an important factor of pregnancy in AID. AID is a safe and reliable assisted reproductive technology similar to spontaneous conception in spontaneous abortion, ectopic pregnancy, pregnancy and childbirth, birth defects and health status.