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用放射免疫法对高原肺水肿(HAPE)患者40例治疗前、后进行了血浆肾素活性(PRA)、血管紧张素Ⅱ(AⅡ)、醛固酮(ALD)、心钠素(ANP)、血清内源性洋地黄因子(EDF)浓度测定,并与急性高原反应(HAAR)患者40例、刚入高原健康者40名比较,发现HAPE组PRA、AⅡ、ALD、ANP浓度显著增高,但EDF低于HAAR组,说明这些生物活性物质水平改变在HAPE的发病机制中起重要作用。
The plasma levels of renin activity (PRA), angiotensin Ⅱ (AⅡ), aldosterone (ALD), atrial natriuretic peptide (ANP), serum EDF concentration was measured and compared with 40 cases of patients with acute altitude sickness (HAAR) and 40 healthy people newly diagnosed with plateau, the concentrations of PRA, AII, ALD and ANP in HAPE group were significantly increased HAAR group, indicating that these changes in the level of bioactive substances play an important role in the pathogenesis of HAPE.