慢性阻塞性肺疾病 (COPD)是一种由慢性支气管炎或肺气肿所引起的气流阻塞与肺部炎症有关的疾病 ,呈进行性发展 ,可伴有气道高反应性 ,气流阻塞可部分被逆转[1] ,其发病机制尚不清楚。呼吸道感染现已被认为是诱发COPD急性加重的重要因素 ,但感染与COPD发病机制之间的因果关系尚 Chronic obstructive pulmonary disease (COPD) is a disorder of airflow obstruction caused by chronic bronchitis or emphysema that is associated with pulmonary inflammation, progres- sionally associated with airway hyperresponsiveness and may be partially obstructed Be reversed [1], its pathogenesis is unclear. Respiratory infections are now considered as an important factor in inducing an acute exacerbation of COPD but the causal relationship between infection and the pathogenesis of COPD