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血管平滑肌细胞（ VSMC）的增殖、迁移是动脉粥样硬化（ As）、高血压和冠状动脉成形术后再狭窄的主要病理表现。而As也是导致心脑血管疾病的重要原因。泛素－蛋白酶体系统是真核细胞内主要的细胞降解系统，而泛素－蛋白酶体抑制剂可以抑制VSMC的增殖及迁移。“,”Vascular smooth muscle cells(VSMC) proliferation,migration are the main pathological man-ifestations of atherosclerosis, hypertension and restenosis after coronary angioplasty.Atherosclerosis is an important cause of cardiovascular and cerebrovascular diseases.The ubiquitin proteasome system is the major intracellular degradation system in eukaryotic cells , and the ubiquitin-proteasome inhibitor can inhibit the proliferation and migration of VSMC.