论文部分内容阅读
目的单因素观察吸入性损伤或烧伤后血清免疫反应性降钙素(iCT)的变化,分析其诊断意义。方法将24只犬随机分为单纯吸入性损伤后中度(A)、重度(B)、特重度损伤(C)组及单纯重度烧伤(D)组,每组6只。吸人性损伤犬均在伤后6 h行纤维支气管镜检查,以明确其损伤程度。分别于不同时相点抽取犬静脉血检测iCT含量,抽取动脉血做血气分析。结果(1)经纤维支气管镜检查,证实A、B、C组犬符合吸入性损伤的预期程度。(2)与伤前值(38±22)ng／L比较,各组吸人性损伤犬iCT含量在伤后1 h均明显升高(P<0．05),伤后4 h明显高于D组(P(0．05),其中A组于24 h达峰值(453±224)ng／L,B、C组在48 h内呈进行性升高。D组犬iCT含量在伤后2 h开始持续升高,至伤后48 h为(125±41)ng／L。(3)血气分析结果显示,与伤前值(109±8)mm Hg (1 mm Hg=0．133 kPa)比较,A、D两组氧分压(PaO2)伤后各时相点无明显差异(P>0．05),B、C组犬从伤后8 h和伤后4 h开始持续下降,分别为(65±6)、(71±9)mm Hg。与二氧化碳分压(PaCO2)的伤前值(38±5)mm Hg比较,C组犬伤后24 h PaCO2开始升高[(52±11)mm Hg]。结论在吸入性损伤后8 h内,iCT的变化明显早于血气分析指标,其诊断意义接近纤维支气管镜检查。
Objective To observe the change of serum immunoreactive calcitonin (iCT) after inhalation injury or burn by single factor and analyze its diagnostic value. Methods Twenty-four dogs were randomly divided into moderate (A), severe (B), severe (C) and severe (B) severe burn group (n = 6). Inhalable injury dogs were examined by fiberoptic bronchoscopy 6 h after injury to determine the degree of injury. At different time points were taken dog venous blood to detect iCT content, blood gas was extracted for arterial blood analysis. Results (1) The bronchoscopy confirmed that the A, B, C group of dogs meet the expected degree of inhalation injury. (2) Compared with the pre-injury value (38 ± 22) ng / L, the content of iCT in each group was significantly increased at 1 h after injury (P <0.05) Group A (P <0.05), in which group A peaked at 24 h (453 ± 224) ng / L, while group B and C increased progressively within 48 h.The content of iCT in group D was significantly higher at 2 h after injury (125 ± 41) ng / L at 48 h after injury. (3) The results of blood gas analysis showed that compared with the pre-injury value of 109 ± 8 mm Hg (1 mm Hg = 0.133 kPa) (P> 0.05). There was no significant difference between the two groups (P> 0.05). The dogs in groups B and C continued to decline from 8 h after injury and from 4 h after injury to (65 ± 6) and (71 ± 9) mm Hg respectively.Compared with pre-injury value (38 ± 5) mm Hg of PaCO2, PaCO2 in C group began to increase 24 hours after injury (52 ± 11 ) mm Hg] .Conclusion Within 8 h after inhalation injury, the change of iCT is earlier than that of blood gas analysis, and its diagnostic significance is close to fibrobronchoscopy.