白塞综合征(BS)是一种慢性、可累及多系统的血管炎性疾病。临床上以口腔溃疡、生殖器溃疡、葡萄膜炎和皮肤损害等反复发作为主要特征,亦可累及胃肠道、关节、心血管、肾脏及神经等多个系统。本病可能与遗传、自身免疫、感染等多种因素有关,其具体发病机制仍不十分清楚。已有研究表明肿瘤坏死因子相关弱凋亡诱导因子(TWEAK)和成纤维细胞生长诱导因子(Fn)14与心脏、脑、肝脏、肾脏、肺部、骨骼肌及关节 Behcet’s syndrome (BS) is a chronic, multi-systemic vascular inflammatory disease. Clinically, oral ulcers, genital ulcers, uveitis and skin lesions and other recurrent episodes as the main feature, but also involving the gastrointestinal tract, joint, cardiovascular, renal and nervous systems. The disease may be genetic, autoimmune, infection and other factors, the specific pathogenesis is still not very clear. Studies have shown that tumor necrosis factor-related weak apoptosis-inducing factor (TWEAK) and fibroblast growth-inducing factor (Fn) 14 interact with heart, brain, liver, kidney, lung, skeletal muscle and joints