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目的综合评估维生素D受体基因BsmI(rs1544410)多态性与冠心病易感性之间的关系。方法计算机检索Pub Med、Web of Science、CNKI、Wan Fang Data、VIP和CBM数据库,搜集维生素D受体基因BsmI(rs1544410)多态性与冠心病易感性的相关病例-对照研究,检索时限均为从建库至2016年5月。由两位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果共纳入7个病例-对照研究,包括2 182例冠心病患者和5 925例对照人群。Meta分析结果显示:总人群中BsmI(rs1544410)B等位基因及BB基因型与冠心病的患病密切相关[Bvs.b:OR=1.36,95%CI(1.03,1.79),P=0.03;BBvs.bb:OR=1.70,95%CI(1.06,2.72),P=0.03;BB+Bb vs.bb:OR=1.52,95%CI(1.00,2.30),P=0.05]。按年龄进行的亚组分析结果显示:BsmI(rs1544410)多态性与年龄<65岁组冠心病患病风险密切相关[Bvs.b:OR=1.65,95%CI(1.00,2.73),P=0.05;BBvs.Bb+bb:OR=1.79,95%CI(1.08,2.97),P=0.02;BBvs.bb:OR=2.64,95%CI(1.12,6.25),P=0.03];按种族进行的亚组分析结果显示:BsmI(rs1544410)多态性与高加索人冠心病患病风险密切相关[Bvs.b:OR=1.47,95%CI(1.10,1.97),P=0.01;BB+Bb vs.bb:OR=1.71,95%CI(1.09,2.68),P=0.02;BBvs.Bb+bb:OR=1.39,95%CI(1.01,1.92),P=0.05;BBvs.bb:OR=1.80,95%CI(1.10,2.95),P=0.02];按基因检测方法进行的亚组分析结果显示:Taq Man方法检测组中BsmI(rs1544410)多态性与冠心病患病风险密切相关[Bvs.b:OR=2.18,95%CI(1.06,4.45),P=0.03;BB+Bb vs.bb:OR=3.32,95%CI(1.06,10.40),P=0.04;BBvs.bb:OR=3.31,95%CI(1.06,10.30),P=0.04];按病例组诊断方法进行的亚组分析结果显示:心电图组中BsmI(rs1544410)多态性与冠心病患病风险密切相关[Bvs.b:OR=1.15,95%CI(1.02,1.29),P=0.02;BB+Bb vs.bb:OR=1.22,95%CI(1.02,1.45),P=0.03;BBvs.bb:OR=1.31,95%CI(1.03,1.67),P=0.03]。结论维生素D受体基因BsmI(rs1544410)B等位基因可能增加冠心病的患病风险,尤其是高加索人和年龄<65岁的人群。
Objective To evaluate the relationship between polymorphism of vitamin D receptor gene BsmI (rs1544410) and susceptibility to coronary heart disease (CHD). Methods The databases of PubMed, Web of Science, CNKI, Wan Fang Data, VIP and CBM were searched by computer. The related case-control study on the polymorphism of vitamin D receptor BsmI (rs1544410) and susceptibility to coronary heart disease From building to May 2016. Two researchers independently screened the literature, extracted data, and assessed the risk of being included in the study. Meta-analysis was performed using RevMan 5.3 software. Results A total of 7 case-control studies were included, including 2 182 coronary heart disease patients and 5 925 control subjects. Meta analysis showed that the BsmI (rs1544410) B allele and BB genotype in the general population were closely related to the prevalence of coronary heart disease [Bvs.b: OR = 1.36,95% CI (1.03,1.79), P = 0.03; BBvs.bb:OR=1.70,95%CI(1.06,2.72),P=0.03;BB+Bb vs.bb:OR=1.52,95%CI(1.00,2.30),P=0.05]. Subgroup analysis by age showed that BsmI (rs1544410) polymorphism was closely related to the prevalence of coronary heart disease in patients <65 years of age [Bvs.b: OR = 1.65,95% CI (1.00,2.73), P = BBvs.bb: OR = 2.64, 95% CI (1.12, 6.25), P = 0.03]; according to race The subgroup analysis showed that BsmI (rs1544410) polymorphism was closely related to the risk of coronary heart disease in Caucasians [Bvs.b: OR = 1.47,95% CI (1.10,1.97), P = 0.01; BB + Bb vs .bb: OR = 1.71, 95% CI (1.09, 2.68), P = 0.02; BBvs.Bb + bb: OR = 1.39, 95% CI (1.01, , 95% CI (1.10, 2.95), P = 0.02]. The subgroup analysis by gene test showed that the BsmI (rs1544410) polymorphism in TaqMan test was closely related to the prevalence of coronary heart disease [Bvs .b: OR = 2.18, 95% CI (1.06, 4.45), P = 0.03; BB + Bb vs. bb: 3.31, 95% CI (1.06,10.30), P = 0.04]. The subgroup analysis by case group showed that BsmI (rs1544410) polymorphism in ECG group was closely related to the risk of coronary heart disease [Bvs. b: OR = 1.15, 95% CI (1.02, 1.29), P = 0.02; BB + Bb vs. bb: OR = 1.22, 95% CI (1.02, 1.45) 0.03; BBvs.bb: OR = 1.31, 95% CI (1.03, 1.67), P = 0.03]. Conclusions The BsmI (rs1544410) B allele of the vitamin D receptor gene may increase the risk of coronary heart disease, especially in Caucasians and those <65 years of age.