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肝癌的血供研究对于肝癌的诊断与治疗具有十分重要的意义。对于肝癌血供的来源,1923年Segall首先提出肝癌只接受来自肝动脉供血的观点,但当时并未得到证实。1954年Breedis等应用墨汁(India ink)作血管灌注证实了原发性肝癌的血供大部分来自肝动脉。以后人们相继应用血管造影、腐蚀技水等,使上述观点得到进一步的证实。1962年Tygstrip应用放射性核素~(133)Xe作肝血流研究,结果发现当肝动脉血流阻断后,肝肿瘤的血流减少90～95％,而正常肝组织血流仅下降35％。基于肝脏肿瘤血供的情况,Markowits首先提出肝动脉阻断治疗肝癌的概念,受到普遍重视。Rainhoff等于1953年利用肝动脉结扎治疗继发性肝癌,使患者的生存期有所延长.但疗效十分短暂.其主要
The research of blood supply of liver cancer has very important significance for the diagnosis and treatment of liver cancer. For the source of liver cancer blood supply, in 1923 Segall first proposed that hepatoma only receives blood from the hepatic artery, but it was not confirmed at that time. In 1954, Breedis and others used Indian ink for vascular perfusion to confirm that the blood supply of primary liver cancer was mostly from the hepatic artery. Later, people applied angiography and corrosion techniques to make the above points further confirmed. In 1962 Tygstrip applied radionuclide ~ (133) Xe for hepatic blood flow studies and found that when hepatic artery blood flow was blocked, blood flow to liver tumors was reduced by 90 to 95%, whereas normal liver tissue blood flow was only decreased by 35%. . Based on the condition of hepatic tumor blood supply, Markowits first proposed the concept of hepatic artery occlusion for the treatment of liver cancer, which received widespread attention. Rainhoff et al used hepatic arterial ligation to treat secondary liver cancer in 1953, which prolonged the survival of the patient. However, the curative effect was very transient.