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目的探讨急性心肌梗死(AMI)患者99mTcHL91乏氧心肌显像的可行性及其临床应用价值。方法15例AMI患者行Tl201和99mTcHL91双核素心肌显像,比较和描述两种核素心肌显像、缺血/存活心肌检测能力以及匹配方式。结果99mTcHL91可以提供较清晰的乏氧心肌图像并用于心肌节段分析;15例AMI患者行双核素显像,共255个节段,即刻Tl201显像示异常节段109个,占43%;99mTcHL91显像示阳性节段160个,占63%。即刻Tl201显像判断为异常的109个节段中,24hTl201延迟显像示40个(部分)可逆性节段(缺血/存活心肌),占37%;99mTcHL91显像示73个阳性节段,占67%,其中40个(部分)可逆节段均呈乏氧阳性显像。99mTcHL91显像检测缺血/存活心肌能力显著高于Tl201(P<0.01)。结论99mTcHL91可以用于AMI患者缺血/存活心肌乏氧成像并用于心肌节段分析。乏氧显像可为研究冠心病提供新手段。
Objective To investigate the feasibility and clinical value of 99m TcHL91 hypoxic myocardial imaging in patients with acute myocardial infarction (AMI). Methods Fifteen patients with acute myocardial infarction (MII) underwent Tl201 and 99mTcHL91 dual - radionuclide myocardial imaging. Their myocardial imaging, myocardial ischemic / viable myocardium detection and matching methods were compared and described. Results 99mTcHL91 can provide a more vivid myocardial imaging and myocardial segment analysis; 15 cases of AMI patients underwent dual-nuclide imaging, a total of 255 segments, immediately Tl201 imaging showed abnormal segments 109, accounting for 43%; 99mTcHL91 Imaging showed 160 positive segments, accounting for 63%. Of the 109 segments identified immediately after Tl201 imaging, 24 (partial) reversible segments (ischemic / viable myocardium) accounted for 37% of the 24 hTl201 delayed images; 73 were positive for 99mTcHL91 imaging, Accounting for 67%, of which 40 (some) reversible segments were hypoxic-positive imaging. 99mTcHL91 imaging was significantly more effective in detecting ischemia / viable myocardium than Tl201 (P <0.01). Conclusion 99mTcHL91 can be used for myocardial ischemia analysis in myocardial infarction patients. Hypoxic imaging can provide a new method for studying coronary heart disease.