论文部分内容阅读
目的:观察小儿喘咳液对喘息性支气管炎患儿的临床疗效,探讨益气祛风理血法治疗小儿喘息性支气管炎的作用机制。方法:将40例患儿随机分为2组各20例。治疗组在常规治疗的基础上加服小儿喘咳液,对照组在常规治疗的基础上加服孟鲁司特钠片,均治疗4周,分别于治疗7天、4周进行疗效评价,并于治疗4周后观察血清白三烯C4(LTC4)水平变化。结果:2组临床疗效、中医证候疗效经秩和检验,差异有显著性或非常显著性意义(P<0.05,P<0.01),治疗组疗效优于对照组。治疗后2组LTC4水平均较治疗前降低,差异有显著性意义(P<0.05);治疗后2组间LTC4水平比较,差异无显著性意义(P>0.05)。随访期间2组患儿喘息复发次数及感冒次数比较,差异均无显著性意义(P>0.05)。结论:小儿喘咳液治疗小儿喘息性支气管炎疗效肯定,其作用途径可能是通过减少LTC4的生成或拮抗白三烯受体来实现。
Objective: To observe the clinical efficacy of pediatric asthma cough solution in children with asthmatic bronchitis, and to explore the mechanism of the therapeutic effect of qi, expelling wind and regulating blood on infantile asthmatic bronchitis. Methods: Forty children were randomly divided into two groups of 20 cases. The treatment group was treated with pediatric asthma cough solution on the basis of routine treatment. The control group was treated with montelukast sodium tablets on the basis of routine treatment for 4 weeks. The therapeutic effects were evaluated at 7 and 4 weeks respectively Changes of serum leukotriene C4 (LTC4) level were observed after 4 weeks of treatment. Results: The curative effect of TCM syndromes in two groups was significant (P <0.05, P <0.01) by rank sum test. The curative effect in treatment group was better than that in control group. After treatment, the levels of LTC4 in both groups were significantly lower than those before treatment (P <0.05). There was no significant difference in LTC4 levels between the two groups after treatment (P> 0.05). There was no significant difference between the two groups in the number of recurrent wheezing and the number of cold during follow-up (P> 0.05). Conclusion: Pediatric asthma cough solution treatment of infantile asthmatic bronchitis positive effect may be through reducing the formation of LTC4 or antagonizing leukotriene receptors to achieve.