类风湿关节炎(rheumatoid arthritis,RA)是一种以慢性进行性侵蚀骨、软骨为主要特征的自身免疫性疾病,其临床表现为以双手和腕关节等小关节受累为主的对称性、持续性多关节炎。RA患者分布于世界各地,在世界范围的流行率为0.5%~1.0%,发病率为30/10万[1]。本病在各年龄段皆可发病,高峰年龄在30~50岁左右,女性较多见。该病病理表现为关节滑膜的慢性炎症及血管翳的形成,并出现关节软骨和骨的破坏。如未给予有效治疗,两年关节侵蚀破坏率达75%,以后病情逐渐加重可造成永久残疾。因此早期诊断、早期治疗至关重要,而血清学检查 Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic progressive erosion of bone and cartilage. Its clinical manifestations are the symmetry of the involvement of small joints such as hands and wrists Polyarthritis. RA patients are distributed throughout the world, prevalence rate of 0.5% to 1.0% worldwide, the incidence rate of 30/10 million [1]. The disease can occur in all age groups, the peak age of 30 to 50 years old, more common in women. The pathological manifestations of chronic inflammation of the synovium and the formation of pannus, and the occurrence of articular cartilage and bone destruction. If not given effective treatment, two years of joint erosion damage rate of 75%, after the gradual increase in the condition can cause permanent disability. Therefore, early diagnosis, early treatment is crucial, and serological tests